[PDF.mJI5] Inflammation in the Pathogenesis of Chronic Diseases 42 (Subcellular Biochemistry)
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Book Details :
Published on: 2007-05-09
Released on: 2007-05-09
Original language:
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The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specific chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the 'COX-2 controversy' regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer’s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents. Nephrotoxicity associated with exposure to chemicals ... international programme on chemical safety environmental health criteria 119 principles amd methods for the assessment of nephrotoxicity associated with exposure ... Enzyme - Wikipedia "Lock and key" model. To explain the observed specificity of enzymes in 1894 Emil Fischer proposed that both the enzyme and the substrate possess specific ... Early pathogenesis of Duchenne muscular dystrophy modelled ... Duchenne muscular dystrophy (DMD) is characterised by progressive muscle atrophy and weakness that eventually leads to ambulatory and respiratory deficiency from ... che.ac.za 201. 202. 203. 204. 205. 206. 207. 208. 209. 210. 211. 212. 213. 214. 215. 216. 217. 218. 219. 220. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 1. 2. 3. 4. 5. 5 120 1 2. 6 120 1 2 ... Autophagy in Human Health and Disease NEJM Review Article. Mechanisms of Disease. Autophagy in Human Health and Disease. Augustine M.K. Choi M.D. Stefan W. Ryter Ph.D. and Beth Levine M.D. Effect of Carvedilol on Survival in Severe Chronic Heart ... Original Article. Effect of Carvedilol on Survival in Severe Chronic Heart Failure. Milton Packer M.D. Andrew J.S. Coats M.D. Michael B. Fowler M.D. Hugo A ... The Role of T Cells in Type 1 Diabetes InTechOpen 1. Introduction. The role of T cells as pathogenic effector cells in type 1 diabetes (T1D) is well established. Both CD4 + and CD8 + cells can play distinct and ... DHA supplementation: Current implications in pregnancy and ... Abstract. Dietary supplementation with -3 long chain fatty acids including docosahexaenoic acid (DHA) has increased in popularity in recent years and adequate DHA ... Cancer as a Metabolic Disease - Medscape The emerging view of cancer as primarily a metabolic disease is predicted to impact approaches to cancer prevention and management. Antioxidant - Wikipedia An antioxidant is a molecule that inhibits the oxidation of other molecules. Oxidation is a chemical reaction that can produce free radicals leading to chain ...
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